- Platelet-rich plasma is obtained from the patient’s own blood sample after centrifugation, which isolates growth factors stimulating tissue repair and regeneration.
- PRP therapy for thin endometrium involves delivering a high concentration of platelets into the uterine cavity, thus promoting the growth of endometrium in women who have not got a response to the conventional hormonal treatment.
- PRP-injected ovarian rejuvenation is the treatment that tries to awaken the inactive follicles and enhance ovarian function in cases of diminished ovarian reserve or premature ovarian insufficiency.
- Each treatment is a low-risk one, done under ultrasound visualization and using the patient’s own blood, which eliminates most of the redox problems.
- PRP therapy can be considered primarily for women with multiple implantation failures, unresponsive thin endometrium, poor ovarian reserve, or for those simply wishing to exhaust all possibilities before donor eggs.
Regenerative medicine has certainly presented new and incredible opportunities in the field of fertility care, and one of the most interesting advances in the field in the last few years is certainly platelet-rich plasma therapy. Traditionally, PRP therapy was used in sports medicine to treat professional athletes who suffered from chronic tendon injuries, muscle injuries, and orthopedic injuries, but it has now been discovered to have a fascinating application in the field of reproductive care, especially for females who struggle with two of the hardest hurdles to conception: a thin endometrium and a low ovarian reserve. Zemya IVF & Fertility Clinics, a High Success Rate IVF clinic in Green Park, is a leading provider of advanced care in the field of reproductive care, especially for females who have failed to adequately respond to traditional therapies.
What Is Platelet Rich Plasma?
Platelet-rich plasma, or PRP, is a platelet concentrate obtained from the blood of the same patient. Blood consists of red blood cells, white blood cells, clotting factors, and plasma, the liquid part in which all these components are suspended. Platelets are small fragments of cells that are crucial for wound healing and, generally, the healing process, as they secrete growth factors that tell the body to fix and regenerate damaged tissues.
To produce PRP, a small volume of blood is taken from the patient and placed inside a centrifuge. Inside the centrifuge, the blood is spun at a high speed. As a result, the platelets are separated from the other components of the blood and placed in the liquid component of the blood. This creates platelet-rich plasma with a much higher level of growth factors than normal blood. When the platelet preparation is injected into the target area, the growth factors stimulate the body cells to heal faster than they normally do with other forms of treatment.
There are mainly two clinical preparations, leukocyte-rich PRP, which keeps the white blood cells, and leukocyte-poor PRP that white blood cells are mostly taken out.
The selection of which among them to use depends on the clinical context and the particular patient’s needs, and the mode of treatment differs accordingly. Zemya IVF & Fertility Clinics, the best IVF doctor in Green Park, conducts the evaluation of each patient thoroughly to decide on the best PRP protocol.
PRP Therapy for Thin Endometrium
The most important obstacle to the successful implantation of an embryo in an IVF cycle is an insufficiently thin endometrial lining. This lining has to be at least seven to eight millimeters thick to provide the right conditions for the embryo to implant and grow. There are women who, despite numerous hormonal preparations for embryo transfer, do not build up enough endometrial thickness. This can be due to adhesions in the uterus, insufficient blood supply to the endometrial lining, past surgical procedures on the uterus, and inflammation. This is one of the main reasons why women do not succeed in their IVF cycles.
Platelet rich plasma injections might be an effective way out for these ladies.
During the intrauterine PRP technique, the PRP that has been prepared is injected straight into the uterine cavity guided by ultrasound, thus a very high concentration of growth factors is delivered straight to the endometrial tissue. These growth factors induce the formation of blood vessels, stimulate cellular proliferation, and facilitate the renewal of a healthier, thicker uterine lining.
Based on the clinical experience of fertility centres worldwide, including the IVF centre near Green Park metro at Zemya IVF & Fertility Clinics, a significant number of women with previously unresponsive thin endometrium have been able to achieve improved lining thickness following the PRP treatment and therefore embryo transfers that were previously cancelled have been able to take place successfully.
The procedure is minimally invasive and well-tolerated, and it is usually done on an outpatient basis without the need for general anesthesia. Most patients feel only mild cramping during the procedure. Otherwise, normal activities may resume on the same day. Results are evaluated with ultrasound after a few weeks to assess if the endometrial response is adequate to proceed with embryo transfer.
PRP Therapy for Ovarian Rejuvenation
The second significant application of platelet rich plasma (PRP) in reproductive medicine is ovarian rejuvenation, which is essentially a method to restore ovarian function in females with diminished ovarian reserve or premature ovarian insufficiency. Such women usually have almost no follicles left, show poor reaction to ovarian stimulation drugs, and have their probabilities of getting pregnant with their own eggs drastically lowered. In fact, for most, the only option that has ever been suggested to them has been IVF with donor eggs.
With PRP therapy for the ovaries, platelet-rich plasma injections are injected into the ovarian tissues. Once again, ultrasound guidance is utilized to ensure proper placement. Growth factors released via the PRP injections are believed to activate dormant follicles, optimize the microenvironment of the ovaries, and enhance blood circulation to the ovarian tissues. This therapy has the potential to activate follicles that were not responding to hormonal stimulation. This is a new and emerging field of reproductive medicine. Current clinical studies have demonstrated that women who have poor ovarian reserves do experience improvements in their ovarian parameters following PRP therapy.
Women who have been told that they can no longer conceive with their own eggs should consider ovarian rejuvenation with PRP therapy. It is a genuinely hopeful option that is very much worth a discussion with a Top fertility specialist in Green Park before one goes ahead with the donor egg treatment. At Zemya IVF & Fertility Clinics, patients are given all the necessary information to make a well-informed decision about this option, and the expectations are always set realistically.
Who Is a Good Candidate for PRP Therapy?
The indication for PRP in the field of fertility treatments is generally considered in the following situations: women with a thin endometrium that has not responded to conventional hormonal treatments, women with diminished ovarian reserve who want to increase their chances of conception with their own eggs, women with premature ovarian insufficiency who want to exhaust all options before considering donor eggs, and women who have experienced recurrent implantation failure in their IVF cycles without any structural reasons.
Like with any fertility procedure, PRP treatment cannot guarantee success for all patients, and results differ from one patient to another.
Since the patient’s own blood is used, the procedure is regarded as safe and the chances of an adverse reaction are very low. The possible risks of the procedure are very few and mainly consist of slight pain at the injection site, a minor risk of infection, and the treatment might not work for some patients.
The team of affordable IVF treatment in Green Park at Zemya IVF & Fertility Clinics makes sure that every patient who is thinking about PRP therapy gets a complete evaluation and receives straightforward, scientifically supported advice on whether they are a good candidate and what results can be expected.
PRP Therapy at Zemya IVF & Fertility Clinics
At Zemya IVF & Fertility Clinics, Male Infertility Treatment in Green Park, Ovarian Rejuvenation, Endometrial PRP, and all other treatments related to Fertility are offered under one roof by a team of experienced and compassionate professionals who believe in using the latest advances in Regenerative Medicine, as well as traditional methods of treatment like IVF, IUI, ICSI, Egg Freezing, and more, to ensure that patients who have failed traditional methods of treatment do not leave our clinic feeling hopeless.
If you are struggling with a thin endometrial lining that is not suitable for embryo transfer, or if your ovarian reserve is so low that you cannot use your eggs, PRP therapy might be an option worth considering. Get in touch with Zemya IVF & Fertility Clinics for a customised consultation with the leading IVF specialist in Green Park and move forward with your fertility journey with a top fertility team.
